The Anti-PCK1/PEPC Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PCK1. This antibody recognizes Human, Mouse, and Rat antigen. The Anti-PCK1/PEPC Antibody has been validated for the following applications: EIA, Immunoassay, Cell Sorting, Isolation, ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized